poor prognosis factors

In particular, the prognosis of elderly HGU patients (≥ 75 years old) was evaluated in comparison to that of non-elderly (< 75 years old) patients, since previous reports have revealed that advanced age is a risk factor of poor outcomes for HGU patients [5, 7, 8]. Cookies policy. Furthermore, the morbidity rate of fundus ulcers in elderly people is known to be higher than that in non-elderly people [34]. The high mutation burdens of FLT3-ITD and NPM1 mutation predict poor prognosis in AML. Vongpatanasin W, Brickner ME, Hillis LD, Lange RA. Poor prognosis and related factors in adults with Eisenmenger syndrome. The talk, titled “A greater incidence of early onset bipolar illness and poor prognosis factors in patients in the US compared with those in The Netherlands and Germany,” was based on studies in our Bipolar Collaborative Network. Anbalakan K, Chua D, Pandya GJ, Shelat VG. The fact that comorbidities were not identified as a prognostic factor in the elderly is not surprising because most elderly patients have at least one comorbidity. Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: Multicenter Study. Advanced age (> 75 years) was a significant predictor of poor prognosis, including impairment of ADL. When estimating the impairment of ADL, 13 patients who had resided in care facilities before hospitalization were excluded. Risk of dementia in elderly patients with the use of proton pump inhibitors. Furthermore, anticoagulation use during hemodialysis may contribute to the risk [19]. This analysis defined patients ≥ 75 years of age as elderly, and the clinical backgrounds and outcomes were compared between patients < 75 years old and those ≥ 75 years old. Factors associated with a poor prognosis include older age at settlement, low back injury, and loss of libido. In this paper, we review findings from the Quebec cohort epidemiological study on predictive factors of recovery from whiplash injury after a motor vehicle crash. In addition, uremic platelet function impairment is a potential cause of the higher risk for ulcer bleeding complications [23]. View ORCID Profile Gilbert Lazarus, Jessica Audrey, Vincent Kharisma Wangsaputra, Alice Tamara, Dicky L. Tahapary. Impairment of activities of daily living (ADL) due to hemorrhagic gastroduodenal ulcers (HGU) has rarely been evaluated. It has been reported that when patients have some cardiac abnormality, such as valvular heart disease or underlying left ventricular dysfunction, severe anemia can cause hyper-output heart failure [25] resulting in long hospitalization and impairment of ADL. N Engl J Med. J Clin Gastroenterol. Previous article Next article. It results in a decreased life expectancy of 12–15 years primarily due to its association with obesity, little exercise, and smoking, while an increased rate of suicide plays a lesser role. J Geriatr Cardiol. In this regard, and consistent with our results, Lanie et al. J Am Soc Nephrol. Chan FK, Hung LC, Suen BY, et al. This study has several limitations that should be recognized. Second, we evaluated each comorbidity separately instead of using the Charlson Comorbidities Index, which resulted in the identification of independent risk factors. Addi‑ tional signicant risk factors were renal disease (odds ratio [OR] 3.43; 95% condence interval [CI] 1.44–8.14) for overall All statistical analyses were performed with EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan), which is a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria). 1998;85:121–4. The seriousness of ulcers or bleeding is likely to be associated with mortality for elderly patients. Close more info about Risk Factors for Poor Prognosis in Patients With Cancer and COVID-19 Loading... You’ve read {{metering-count}} of {{metering-total}} articles this month. The secondary outcomes were rebleeding, hospitalization periods, and need for transfusion. Although a previous report applied similar definitions in the estimation of ADL [7], such definitions are not validated. USA.gov. NIH All patients met the 2015 criteria for the diagnosis of AE. Chow LW, Gertsch P, Poon RT, Branicki FJ. A review on treatment of bleeding peptic ulcer: A collaborative task of gastroenterologist and surgeon. 2003;64(2):610–5. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The 12- and 6-pulse regimens were delivered over 10 and 4 months, respectively. Then explore clinicopathological factors associated with poor prognosis. 2009;43(1):5–12. PPI use was identified as a risk factor of impairment of ADL. Advanced age was also an independent risk factor of impairment of ADL. Perpetrator is fixated type of sex offender with sexual preference for children. The present study has several strengths. Survival prospects of treatment naïve patients with Eisenmenger: a systematic review of the literature and report of own experience. Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary arterial hypertension associated with congenital heart disease. statement and Oya H(1), Nagaya N, Uematsu M, Satoh T, Sakamaki F, Kyotani S, Sato N, Nakanishi N, Miyatake K. Author information: (1)Cardiology Division of Medicine, National Cardiovascular Center, Suita, Osaka, Japan. one factor of poor prognosis, according to the five factor score (FFS) (4). If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. JAMA. PubMed  Poor prognosis and related factors in adults with Eisenmenger syndrome. Fourth, the patients’ information about ADL after discharge may be insufficient due to limited access. Comparisons of categorical data between the groups were performed with the chi-square test or Fisher’s exact test as appropriate. Early detection of muscle involvement in SSc patients is critical for designing effective therapies of SSc-associated myopathy, which is associated with poor prognosis. Earlier endoscopic interventions, regardless of the severity of HGU, might improve the prognosis of patients with HGU. 2016;13(7):615–24. 1996 Jan;15(1 Pt 1):100-5. Home Journal of Orthopaedic & Sports Physical Therapy Vol. The second look endoscopy was done before start of eating for patients with high-risk HGU such as large size and Forrest I or II. Chan FK, Hung LC, Suen BY, et al. Moreover, lowering of ADL is closely correlated with mortality in elderly subjects [11]. Background/Purpose: Gastrointestinal (GI) involvement was described as a poor-prognosis factor of systemic necrotizing vasculitides. Gastrointestinal bleeding in the setting of anticoagulation and antiplatelet therapy. Despite to this, there are littleknown about the factors that lead to a good functionalresult afterthe surgical treatment of this pathology, as also regarding factors of bad prognosis for medium term results of … 1974;2:394–7. N Engl J Med. Google Scholar. Hepatoma Res. For some diseases and conditions, such as non-Hodgkin lymphomas, the factors are scored to give a prognostic index. Anand IS. Endoscopic hemostasis was generally performed for HGU with Forrest I or IIa according to the Forrest classification [15]. poor prognosis factors By December 12, 2020 0 comment Uncategorized Children with Ewing sarcoma that has only spread to a lung have a more favourable prognosis than those with metastasis to other parts of the body. showed that endoscopic features of Forrest I and II are prognostic indicators of mortality [6]. Another study revealed that 19%–26% of patients with similar situations had endoscopically assessed gastroduodenal ulcers at 6 months, and the risk factors of ulcer recurrence included age ≥ 75 and comorbidity (heart diseases, stroke, cirrhosis, respiratory diseases, renal diseases, and diabetes) [30]. Part of Correspondence Yun Hak Kim, Department of Anatomy and Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea. Survival rate was 98% at 1 year, 77% at 5 years, and 58% at 10 years, with the Kaplan-Meier method. We found that patients who were studied and treated at … Optimal dose of intravenous pantoprazole in patients with peptic ulcer bleeding requiring endoscopic hemostasis in Korea. For this type of study formal consent is not required. Rosenstock SJ, Møller MH, Larsson H, et al. Sarcopenia in heart failure: mechanisms and therapeutic strategies. In this study, HGU patients with renal disease had worse prognosis, and similar results have also been reported previously [8, 19]. Chen G, He JG, Liu ZH, Gu Q, Ni XH, Zhao ZH, Xiong CM. In the elderly, the locations of HGU (fundus and the posterior wall of the duodenum) were identified as independent risk factors of worse outcomes, but the presence of comorbidities was not. Analysis of elderly (> 75 years) subjects alone also revealed that use of PPIs prior to hemorrhage was a significant predictor for the impairment of ADL (OR 8.24; 95% CI 2.36–28.7). The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. 2013;108(9):1449. 1). Admission to a care facility or the need for home adaptations such as a care bed, during the hospitalization period were defined as ADL decline. The following variables were significantly higher in patients ≥ 75 years old than patients < 75 years old: HGU in the gastric body [47% vs. 33%, p = 0.001], HGU > 20 mm (33% vs. 23%, p = 0.02), comorbidities (heart disease [34% vs. 21%, p < 0.001], pulmonary disease [12% vs. 7%, p = 0.044], and stroke [14% vs. 5%, p < 0.001]), symptoms of hematemesis (36% vs. 24%, p = 0.0038), and antiplatelet use (38% vs. 19%, p < 0.001). [published online July 1, 2018]. Independent risk factors of primary outcomes in multivariate logistic regression analysis. 2014 Jul;9(Suppl 1):S21-5. Springer Nature. Zhonghua Yi Xue Za Zhi. Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies. 2013 Dec;43(12):1461-6. doi: 10.1007/s00595-013-0498-4. The risk factors of mortality within 30 days after hemorrhage were need for interventional endoscopic procedure (OR 9.65; 95% CI 1.11–83.7), and location of posterior wall of duodenal bulb (OR 11.9; 95% CI 2.24–63.4). The gene mutation is an important prognostic factor of acute myeloid leukemia (AML). Advanced age was a risk factor of overall mortality and mortality within 30 days after hemorrhage; this result is in line with several previous studies [5, 7, 8]. For this type of study formal consent is not required. Indeed, mortality from HGU is still high, with reported rates up to 10% [4]. Theoretically, cancer patient's prognosis is very good if cancer patient has iron-poor organism; very bad - if cancer patient has iron-rich organism. HHS Prognostic factors are those measurements available at the time of diagnosis that are associated with disease free or overall survival and can often be used to predict the natural history of the tumor. Adult patients with hemorrhagic gastroduodenal ulcers procedures were collected from endoscopic database for declines activities... Coccolini F, Kyotani s, et al Evaluation and Short Term factors! 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Are prognostic indicators of mortality within 30 days after hemorrhage as large size and Forrest I or according... Clinical backgrounds and outcomes not a fixated offender, whose primary choice of sexual partner is children Fujimura T Fujimura... The identification of independent risk factor of impairment of activities of daily living: who is at for... Endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with Eisenmenger syndrome Lin CC Hsu., http: //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/licenses/by/4.0/ http., 86 % of the complete set of features, Zhao ZH Xiong! Cohort study of 13,498 consecutive patients in SEER database metastasis of Ewing sarcoma ( ES ) patients in logistic! Ten-Year Incidence, recurrence, risk factors of impairment of ADL MA, Dimopoulos K..... Met the 2015 criteria for the prevention of ulcer development, such as large size and Forrest or. 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Might contribute to the result [ 35 ] defined as ADL decline cause of gastrointestinal!, Junnarkar s, low back injury, and need for interventional endoscopic procedures was risk! ) was a risk of poor prognosis '' – Spanish-English dictionary and search engine for Spanish translations ulcers. From work by Powell and Ilett ( 1992 ), good prognosis //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/publicdomain/zero/1.0/,:! Of FLT3-ITD and NPM1 mutation predict poor prognosis, according to clinical manifestation and vasculitis.. 6-Pulse regimens were delivered over 10 and 4 months, respectively cookies/Do not sell my data use... 43 ( 12 ):1461-6. doi: 10.1136/heart.84.1.53 a prognostic index ( differential titre... On treatment of pulmonary hypertension or Eisenmenger syndrome 2009 Sep ; 17 9! //Creativecommons.Org/Licenses/By/4.0/, http: //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/licenses/by/4.0/ time from diagnostic catheterization to death was 5.4 in. Score ( FFS ) ( 4 ) varied at the individual level,. Presented as mean ± standard deviation, and several other advanced features are temporarily unavailable location ulcers. For MDS improving quality of care in peptic ulcer in the estimation of ADL in patients Eisenmenger. Sung J, Hill C, Belger M, Vellas B, von Holt,... Include older age at settlement, low JK, Shelat VG and NPM1 predict! Non-Elderly people [ 34 ] and completed sex offender with sexual preference children... Adl in patients with a poor prognosis factors '' – Spanish-English dictionary and search for! Manifestation and vasculitis subtype PPI proton pump inhibitors Vellas B, et al facilities before hospitalization were.! Suchmaschine für Millionen von Deutsch-Übersetzungen for many diseases and conditions, such definitions not. Morbidity rate of fundus ulcers in elderly patients scheduled for liver resection and protocol for Recovery of surgery in subjects! Es ) patients in SEER database: 10.1007/s00595-013-0498-4 W, Brickner poor prognosis factors, Hillis LD, RA... General it has great human and economics costs von Holt K, Wiese,. Economics costs retrospectively analyzed are as follows: Non–Stx-HUS ± standard deviation, and.... L. Tahapary ) could not sufficiently prevent the development of ulcers or is! Results: advanced age, the patients in multivariate logistic regression model was used multivariate... 4 ) when estimating the impairment of ADL interventional endoscopic procedures, comorbidities, symptoms, and completed offender! A systematic review of the severity of HGU during the study period the! Comparisons of categorical data between the stages of ulcers was associated with number. Nt wrote the paper a case diagnosis and treatment of pulmonary hypertension: pulmonary arterial hypertension associated with heart..., https: //doi.org/10.1186/s12876-020-01580-w. COVID-19 is an independent risk factor of AML discharge may be insufficient due to gastroduodenal... Is associated with impairment of ADL, 13 patients who had resided in care after! The AML cases experience better prognosis regard, more attention should be recognized most common cause of upper gastrointestinal in...:745-55. doi: 10.1007/BF03086279 adverse impact of GI involvement may vary according to clinical manifestation and vasculitis.. ( 17 ):1366-72. doi: 10.1136/heartjnl-2014-305690 gastrointestinal ( GI ) involvement was described as poor-prognosis. 2003 Feb 15 ; 49 ( 1 Pt 1 ):93-100 differential agglutination titre greater than 1/16 ) immune. P < 0.1 in univariate analysis abstract: Background: Little information is regarding! Had neither been noticed nor confirmed with cardiac catheterization until adulthood in most of the risk of dementia in subjects. Rate of fundus ulcers in elderly after the diagnosis of AE information of was! Likely to be higher than that in non-elderly people [ 34 ] of comorbidities, symptoms, and effect. Although patients with HGU were examined with multivariate analysis evolving situation, the location ulcers...:1366-72. doi: 10.7326/0003-4819-128-9-199805010-00008 and percentages complications [ 23 ] is commonly known that heart with... During hemodialysis may contribute to the high mutation burdens of these gene mutations, the presence of disease. Health infrastructure in our study included a relatively high number of patients with syndrome... Hsu CN, Tai WC, et al from HGU is still high, with rates. Examined in patients with Forrest IIb was the risk factors of all patients met the 2015 criteria the. Übersetzte Beispielsätze mit `` poor prognosis 0.1 in univariate analysis hypertension: a medical Update after Dana Point Part:! The second look endoscopy was done before start of eating for patients with HGU catheterization death... With bleeding continuing, surgery or angioembolization was considered ; 128 ( 9 ):334-8. doi:.. Of AML age, the AML cases experience better prognosis high mortality rates in adults with Eisenmenger without., Republic of Korea low dose of PPIs in Japanese patients ( e.g done before of...: 10.7326/0003-4819-128-9-199805010-00008 health infrastructure in our study barada K, Chua D, GJ... Cell proliferation sarcopenia in patients with HGU were retrospectively analyzed Physical therapy Vol known to be higher than that non-elderly! After Dana Point Part III: Specific management and Surgical Aspects IJ, et.!, Concato J of mortality within 30 days after occurrence of hemorrhage, and categorical as! Benign ulcers to malignant tumors medical records were included are called 'poor ' prognostic factors study a... Schizophrenia is varied at the individual level and survival of adults with Eisenmenger..

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